The Schistosoma gene discovery program:: state of the art

被引：38

作者：

Franco, GR

Valadao, AF

Azevedo, V

Rabelo, ÉML

机构：

[1] Univ Fed Minas Gerais, ICB, Dept Bioquim & Imunol, BR-31270010 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, ICB, Dept Biol Geral, BR-31270010 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, ICB, Dept Parasitol, BR-31270010 Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2000年 / 30卷 / 04期

关键词：

bioinformatics; cluster analysis; differential gene expression; expressed sequence tags; gene discovery; Schistosoma Genome Project;

D O I：

10.1016/S0020-7519(00)00020-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Schistosoma are dioecious digenetic trematodes carrying a large (270 Mb) genome. Gaining knowledge about the genome of these parasites is of importance for the understanding of their biology, mechanisms of drug resistance and antigenic variation that determine escape from the host's immune system. This review will provide an update on the Schistosoma Gene Discovery Program, which is part of the Schistosoma Genome Project created in 1992. One of the main objectives of this program is the discovery and characterisation of new genes of Schistosoma mansoni and Schistosoma japonicum in an attempt to search for new targets for drugs and vaccine development. The success of the Schistosoma Gene Discovery Program is demonstrated by the number of catalogued genes, that now reaches 15 to 20% of the full gene complement of its genome, (C) 2000 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：453 / 463

页数：11

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[21] Life with 6000 genes [J].