共 21 条
Modulation of notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
被引:448
作者:

Milano, J
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

McKay, J
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Dagenais, C
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Foster-Brown, L
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Pognan, F
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Gadient, R
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Jacobs, RT
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Zacco, A
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Greenberg, B
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA

Ciaccio, PJ
论文数: 0 引用数: 0
h-index: 0
机构: AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA
机构:
[1] AstraZeneca, Mol & Invest Toxicol, Safety Assessment US, Wilmington, DE 19850 USA
[2] AstraZeneca, DMPK, Wilmington, DE 19850 USA
[3] AstraZeneca, Neurosci, Wilmington, DE 19850 USA
[4] AstraZeneca, Target Biol, Wilmington, DE 19850 USA
[5] AstraZeneca, Chem, Wilmington, DE 19850 USA
[6] AstraZeneca, Safety Assessment UK, Macclesfield SK10 4TG, Cheshire, England
关键词:
gamma-secretase;
Notch receptor;
Notch intracellular domain;
NICD;
intestinal goblet metaplasia;
Rath1;
Hes1;
adipsin;
atonal;
D O I:
10.1093/toxsci/kfh254
中图分类号:
R99 [毒物学(毒理学)];
学科分类号:
100405 ;
摘要:
It is anticipated that gamma-secretase inhibitors (gamma-Sec-I) that modulate Notch processing will alter differentiation in tissues whose architecture is governed by Notch signaling. To explore this hypothesis, Han Wistar rats were dosed for up to 5 days with 10-100 mumol/kg b.i.d. gamma-Sec-I from three chemical series that inhibit Notch processing in vitro at various potencies (Notch IC50). These included an arylsulfonamide (AS) (142 nM), a dibenzazepine (DBZ) (1.7 nM), and a benzodiazepine (BZ) (2.2 nM). The DBZ and BZ caused dose-dependent intestinal goblet cell metaplasia. In contrast, the AS produced no detectable in vivo toxicity, despite higher exposure to free drug. In a time course using BZ, small intestinal crypt cell and large intestinal glandular cell epithelial apoptosis was observed on days 1-5, followed by goblet cell metaplasia on days 2-5 and crypt epithelial and glandular epithelial regenerative hyperplasia on days 4-5. Gene expression profiling of duodenal samples from BZ-dosed animals revealed significant time-dependent deregulation of mRNAs for various panendocrine, hormonal, and transcription factor genes. Somatostatin, secretin, mucin, CCK, and gastrin mRNAs were elevated twofold or more by day 2, and a number of candidate 'early-predictive' genes were altered on days 1-2, remaining changed for 4-5 days; these included Delta1, NeuroD, Hes1-regulated adipsin, and the Hes-regulated transcriptional activator of gut secretory lineage differentiation, the rat homolog of Drosophila atonal, Rath1. Western blotting of fecal protein from BZ-and DBZ-dosed animals exhibited increased levels of both anti-Rath1 reactive protein and anti-adipsin reactive proteins, confirming their potential value as noninvasive biomarkers of intestinal goblet metaplasia.
引用
收藏
页码:341 / 358
页数:18
相关论文
共 21 条
[1]
P-glycoprotein: from genomics to mechanism
[J].
Ambudkar, SV
;
Kimchi-Sarfaty, C
;
Sauna, ZE
;
Gottesman, MM
.
ONCOGENE,
2003, 22 (47)
:7468-7485

Ambudkar, SV
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Kimchi-Sarfaty, C
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Sauna, ZE
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Gottesman, MM
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[2]
An overview of the Notch signalling pathway
[J].
Baron, M
.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY,
2003, 14 (02)
:113-119

Baron, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[3]
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
[J].
Dovey, HF
;
John, V
;
Anderson, JP
;
Chen, LZ
;
Andrieu, PD
;
Fang, LY
;
Freedman, SB
;
Folmer, B
;
Goldbach, E
;
Holsztynska, EJ
;
Hu, KL
;
Johnson-Wood, KL
;
Kennedy, SL
;
Kholedenko, D
;
Knops, JE
;
Latimer, LH
;
Lee, M
;
Liao, Z
;
Lieberburg, IM
;
Motter, RN
;
Mutter, LC
;
Nietz, J
;
Quinn, KP
;
Sacchi, KL
;
Seubert, PA
;
Shopp, GM
;
Thorsett, ED
;
Tung, JS
;
Wu, J
;
Yang, S
;
Yin, CT
;
Schenk, DB
;
May, PC
;
Altstiel, LD
;
Bender, MH
;
Boggs, LN
;
Britton, TC
;
Clemens, JC
;
Czilli, DL
;
Dieckman-McGinty, DK
;
Droste, JJ
;
Fuson, KS
;
Gitter, BD
;
Hyslop, PA
;
Johnstone, EM
;
Li, WY
;
Little, SP
;
Mabry, TE
;
Miller, FD
;
Ni, B
.
JOURNAL OF NEUROCHEMISTRY,
2001, 76 (01)
:173-181

Dovey, HF
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

John, V
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Anderson, JP
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Chen, LZ
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Andrieu, PD
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Fang, LY
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Freedman, SB
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Folmer, B
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Goldbach, E
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Holsztynska, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Hu, KL
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Johnson-Wood, KL
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Kennedy, SL
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Kholedenko, D
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Knops, JE
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Latimer, LH
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Lee, M
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Liao, Z
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Lieberburg, IM
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Motter, RN
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Mutter, LC
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Nietz, J
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Quinn, KP
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Sacchi, KL
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Seubert, PA
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Shopp, GM
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Thorsett, ED
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Tung, JS
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Wu, J
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Yang, S
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Yin, CT
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Schenk, DB
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

May, PC
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Altstiel, LD
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Bender, MH
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Boggs, LN
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Britton, TC
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Clemens, JC
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Czilli, DL
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Dieckman-McGinty, DK
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Droste, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Fuson, KS
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Gitter, BD
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Hyslop, PA
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Johnstone, EM
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Li, WY
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Little, SP
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Mabry, TE
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Miller, FD
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA

Ni, B
论文数: 0 引用数: 0
h-index: 0
机构: Elan Pharmaceut Inc, S San Francisco, CA 94080 USA
[4]
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
[J].
Holcomb, LA
;
Gordon, MN
;
Jantzen, P
;
Hsiao, K
;
Duff, K
;
Morgan, D
.
BEHAVIOR GENETICS,
1999, 29 (03)
:177-185

Holcomb, LA
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA

Gordon, MN
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA

Jantzen, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA

Hsiao, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA

Duff, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA

Morgan, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33612 USA
[5]
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
[J].
Jenny, M
;
Uhl, C
;
Roche, C
;
Duluc, I
;
Guillermin, V
;
Guillemot, F
;
Jensen, J
;
Kedinger, M
;
Gradwohl, G
.
EMBO JOURNAL,
2002, 21 (23)
:6338-6347

Jenny, M
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Uhl, C
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Roche, C
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Duluc, I
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Guillermin, V
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Guillemot, F
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Jensen, J
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Kedinger, M
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France

Gradwohl, G
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U381, F-67200 Strasbourg, France
[6]
Control sf endodermal endocrine development by Hes-1
[J].
Jensen, J
;
Pedersen, EE
;
Galante, P
;
Hald, J
;
Heller, RS
;
Ishibashi, M
;
Kageyama, R
;
Guillemot, F
;
Serup, P
;
Madsen, OD
.
NATURE GENETICS,
2000, 24 (01)
:36-44

Jensen, J
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Pedersen, EE
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Galante, P
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Hald, J
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Heller, RS
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Ishibashi, M
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Kageyama, R
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Guillemot, F
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Serup, P
论文数: 0 引用数: 0
h-index: 0
机构: Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark

Madsen, OD
论文数: 0 引用数: 0
h-index: 0
机构:
Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark Hagedorn Res Lab, Dept Dev Biol, Gentofte, Denmark
[7]
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
[J].
Jung, KM
;
Tan, S
;
Landman, N
;
Petrova, K
;
Murray, S
;
Lewis, R
;
Kim, PK
;
Kim, DS
;
Ryu, SH
;
Chao, MV
;
Kim, TW
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (43)
:42161-42169

Jung, KM
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Tan, S
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Landman, N
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Petrova, K
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Murray, S
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Lewis, R
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Kim, PK
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Kim, DS
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Ryu, SH
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Chao, MV
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

Kim, TW
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, Dept Pathol,Ctr Neurobiol & Behav, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
[8]
The bHLH gene Hes1 regulates differentiation of multiple cell types
[J].
Kageyama, R
;
Ohtsuka, T
;
Tomita, K
.
MOLECULES AND CELLS,
2000, 10 (01)
:1-7

Kageyama, R
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan

Ohtsuka, T
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan

Tomita, K
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan
[9]
The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments
[J].
LaVoie, MJ
;
Selkoe, DJ
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (36)
:34427-34437

LaVoie, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Boston, MA 02215 USA

Selkoe, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Boston, MA 02215 USA
[10]
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
[J].
Lee, CS
;
Perreault, N
;
Brestelli, JE
;
Kaestner, KH
.
GENES & DEVELOPMENT,
2002, 16 (12)
:1488-1497

Lee, CS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Perreault, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Brestelli, JE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Kaestner, KH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA