Cholestasis Induced by Total Parenteral Nutrition

被引：76

作者：

Guglielmi, Francesco William ^{[1
]}

Regano, Nunzia ^{[1
]}

Mazzuoli, Silvia ^{[1
]}

Fregnan, Simona ^{[1
]}

Leogrande, Giuseppina ^{[1
]}

Guglielmi, Altomarino ^{[2
]}

Merli, Manuela ^{[3
]}

Pironi, Loris ^{[4
]}

Moran Penco, J. M. ^{[5
]}

Francavilla, Antonio ^{[6
]}

机构：

[1] Hosp San Nicola Pellegrino, Sect Gastroenterol & Artificial Nutr, I-70059 Bari, Italy

[2] Univ Bari, Dept Emergency & Organ Transplantat, Sect Gen Surg Univ Francesco Paccione 2, Bari, Italy

[3] Univ Roma La Sapienza, Cattedra Gastroenterol 2, Rome, Italy

[4] Univ Bologna, Dept Internal Med & Gastroenterol, S Orsola M Malpighi Hosp, Ctr Chron Intestinal Failure, Bologna, Italy

[5] Univ Extremadura, Dept Surg, Fac Med, Badajoz, Spain

[6] Univ Bari, Gastroenterol Sect, Dept Emergency & Organ Transplantat, Bari, Italy

来源：

CLINICS IN LIVER DISEASE | 2008年 / 12卷 / 01期

关键词：

D O I：

10.1016/j.cld.2007.11.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Parenteral nutrition is a life-saving treatment for patients who have acute and chronic intestinal failure. Severe cholestasis induced by total parental nutrition (TPN-IC) is characterized by bile duct regeneration, portal inflammation, and fibrosis. Its progression could be very rapid, and in some patients liver cirrhosis may develop in few months. This article describes the definition, incidence, hepatic changes, histopathologic findings, risk factors, pathogenesis, and clinical implications of TPN-IC. The goal is to improve hospital and home management, quality of life, and prognosis of patients requiring parenteral nutrition.

引用

页码：97 / +

页数：15

共 74 条

[1]

Al-Hathlol K., 2006, SMJ Singapore Medical Journal, V47, P147

[2]

ALADE SL, 1986, PEDIATRICS, V77, P593

[3]

Male sex predisposes the newborn surgical patient to parenteral nutrition-associated cholestasis and to sepsis [J].

Albers, MJIJ ;

de Gast-Bakker, DAH ;

van Dam, NAM ;

Madern, GC ;

Tibboel, D .

ARCHIVES OF SURGERY, 2002, 137 (07) :789-793

[4]

ALLARDYCE DB, 1982, SURG GYNECOL OBSTET, V154, P641

[5]

THE EFFECT OF PARENTERAL-NUTRITION ON GASTROINTESTINAL IMMUNITY - THE IMPORTANCE OF ENTERAL STIMULATION [J].

ALVERDY, J ;

CHI, HS ;

SHELDON, GF .

ANNALS OF SURGERY, 1985, 202 (06) :681-684

[6]

BALISTRIERI WF, 1998, J PEDIAT GASTROENTER, V2, P346

[7]

BEALE EF, 1979, PEDIATRICS, V63, P110

[8]

Parenteral nutrition-related cholestasis in postsurgical neonates: Multivariate analysis of risk factors [J].

Beath, SV ;

Davies, P ;

Papadopoulou, A ;

Khan, AR ;

Buick, RG ;

Corkery, JJ ;

Gornall, P ;

Booth, IW .

JOURNAL OF PEDIATRIC SURGERY, 1996, 31 (04) :604-606

[9]

IS URSODEOXYCHOLIC ACID AN EFFECTIVE THERAPY FOR TOTAL PARENTERAL NUTRITION-RELATED LIVER-DISEASE [J].

BEAU, P ;

LABATLABOURDETTE, J ;

INGRAND, P ;

BEAUCHANT, M .

JOURNAL OF HEPATOLOGY, 1994, 20 (02) :240-244

[10]

TOTAL PARENTERAL NUTRITION-RELATED CHOLESTASIS IN INFANTS [J].

BELL, RL ;

FERRY, GD ;

SMITH, EO ;

SHULMAN, RJ ;

CHRISTENSEN, BL ;

LABARTHE, DR ;

WILLS, CA .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1986, 10 (04) :356-359

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