Switching the flip: protein phosphatase roles in signaling pathways

被引：72

作者：

DeLong, Alison ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2006年 / 9卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.pbi.2006.07.015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Protein phosphatases are the obligate partners of protein kinases in cellular control circuitry. Several specific roles of phosphatases have been revealed in plant systems through recent work capitalizing on functional genomics, interaction screens and activation-tagging approaches. Historically, the redundancy of genes that encode phosphatase functions has impeded genetic analysis in plant systems, and relatively few elucidated signaling pathways include protein phosphatases that have clearly defined substrates. Functional genomics, interaction and suppression screens, activation tagging and phosphoproteomics now hold great promise for identifying phosphatases that are active in signaling and regulation, and for revealing their in vivo substrates. This level of analysis will be essential for a full understanding of the effects of reversible protein phosphorylation in modulating and integrating cellular activities.

引用

页码：470 / 477

页数：8

共 64 条

[1]

Andreeva Alexandra V., 2001, Molecular Cell Biology Research Communications, V4, P345, DOI 10.1006/mcbr.2001.0302

[2] The structure and mechanism of protein phosphatases: Insights into catalysis and regulation [J].

Barford, D ;

Das, AK ;

Egloff, MP .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1998, 27 :133-164

[3] Receptor kinase signaling in plant development [J].

Becraft, PW .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2002, 18 :163-192

[4] The Arabidopsis TONNEAU2 gene encodes a putative novel protein phosphatase 2A regulatory subunit essential for the control of the cortical cytoskeleton [J].

Camilleri, C ;

Azimzadeh, J ;

Pastuglia, M ;

Bellini, C ;

Grandjean, O ;

Bouchez, D .

PLANT CELL, 2002, 14 (04) :833-845

[5] Functional diversity of protein phosphatase-1, a cellular economizer and reset button [J].

Ceulemans, H ;

Bollen, M .

PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :1-39

[6] Novel protein serine/threonine phosphatases: Variety is the spice of life [J].

Cohen, PTW .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :245-251

[7] Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis [J].

Czechowski, T ;

Stitt, M ;

Altmann, T ;

Udvardi, MK ;

Scheible, WR .

PLANT PHYSIOLOGY, 2005, 139 (01) :5-17

[8] The RCN1-encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo [J].

Deruère, J ;

Jackson, K ;

Garbers, C ;

Söll, D ;

DeLong, A .

PLANT JOURNAL, 1999, 20 (04) :389-399

[9] PhosphoThr peptide binding globally rigidifies much of the FHA domain from Arabidopsis receptor kinase-associated protein phosphatase [J].

Ding, ZF ;

Lee, G ;

Liang, XY ;

Gallazzi, F ;

Arunima, A ;

Van Doren, SR .

BIOCHEMISTRY, 2005, 44 (30) :10119-10134

[10] Hormonal studies of fass, an Arabidopsis mutant that is altered in organ elongation [J].

Fisher, RH ;

Barton, MK ;

Cohen, JD ;

Cooke, TJ .

PLANT PHYSIOLOGY, 1996, 110 (04) :1109-1121

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