Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions

被引：114

作者：

Arble, Deanna M. ^{[1
]}

Bass, Joseph ^{[2
]}

Behn, Cecilia Diniz ^{[3
]}

Butler, Matthew P. ^{[4
]}

Challet, Etienne ^{[5
]}

Czeisler, Charles ^{[6
,7
]}

Depner, Christopher M. ^{[8
]}

Elmquist, Joel ^{[9
,10
,11
]}

Franken, Paul ^{[12
]}

Grandner, Michael A. ^{[13
]}

Hanlon, Erin C. ^{[14
]}

Keene, Alex C. ^{[15
]}

Joyner, Michael J. ^{[16
]}

Karatsoreos, Ilia ^{[17
]}

Kern, Philip A. ^{[18
,19
]}

Klein, Samuel ^{[20
]}

Morris, Christopher J. ^{[6
,7
]}

Pack, Allan I. ^{[21
,22
]}

Panda, Satchidananda ^{[23
]}

Ptacek, Louis J. ^{[24
]}

Punjabi, Naresh M. ^{[25
]}

Sassone-Corsi, Paolo ^{[26
]}

Scheer, Frank A. ^{[6
,7
]}

Saxena, Richa ^{[27
,28
]}

Seaquest, Elizabeth R. ^{[29
]}

Thimgan, Matthew S. ^{[30
]}

Van Cauter, Eve ^{[31
]}

Wright, Kenneth P. ^{[8
,32
]}

机构：

[1] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

[2] Northwestern Univ, Dept Med, Div Endocrinol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Colorado Sch Mines, Dept Appl Math & Stat, Golden, CO 80401 USA

[4] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, Portland, OR 97201 USA

[5] Univ Strasbourg, CNRS, Inst Cellular & Integrat Neurosci, Strasbourg, France

[6] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

[8] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA

[9] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[10] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[11] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[12] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[13] Univ Arizona, Dept Psychiat, Tucson, AZ USA

[14] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[15] Univ Nevada, Dept Biol, Reno, NV 89557 USA

[16] Mayo Clin, Dept Anesthesiol, Rochester, MN USA

[17] Washington State Univ, Coll Vet Med, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA

[18] Univ Kentucky, Dept Med, Div Endocrinol, Lexington, KY 40506 USA

[19] Univ Kentucky, Ctr Clin & Translat Sci, Lexington, KY USA

[20] Washington Univ, Sch Med St Louis, Ctr Human Nutr, St Louis, MO USA

[21] Univ Penn, Perelman Sch Med, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA

[22] Univ Penn, Perelman Sch Med, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA

[23] Salk Inst Biol Studies, Regulatory Biol Lab, La Jolla, CA 92037 USA

[24] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Neurol, San Francisco, CA 94143 USA

[25] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[26] Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92717 USA

[27] Massachusetts Gen Hosp, Dept Anesthesia, Boston, MA 02114 USA

[28] Harvard Univ, Sch Med, Boston, MA USA

[29] Univ Minnesota, Dept Med, Div Endocrinol Diabet & Metab, Minneapolis, MN 55455 USA

[30] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO USA

[31] Univ Chicago, Sleep Metab & Hlth Ctr, Chicago, IL 60637 USA

[32] Univ Colorado, Div Endocrinol Diabet & Metab, Aurora, CO USA

来源：

SLEEP | 2015年 / 38卷 / 12期

关键词：

circadian disruption; circadian rhythm; diabetes; insulin resistance; metabolism; obesity; short sleep; sleep apnea; sleep disorders; CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE; HIGH-FAT-DIET; HIGH CALORIC-INTAKE; INSULIN-RESISTANCE; CAROTID-BODY; WEIGHT-GAIN; FOOD-INTAKE; GLUCOSE-METABOLISM; HUMAN ADIPOCYTES;

D O I：

10.5665/sleep.5226

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.

引用

页码：1849 / 1860

页数：12

共 123 条

[1] Circadian Timing of Food Intake Contributes to Weight Gain [J].