Carbon nanotube aqueous sol-gel composites: enzyme-friendly platforms for the development of stable biosensors

被引：90

作者：

Gavalas, VG

Law, SA

Ball, JC

Andrews, R

Bachas, LG ^{[1
]}

机构：

[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

[2] Univ Kentucky, Adv Carbon Mat Ctr, Lexington, KY 40506 USA

[3] Univ Kentucky, Ctr Appl Energy Res, Lexington, KY 40511 USA

[4] Univ Kentucky, Adv Carbon Mat Ctr, Lexington, KY 40511 USA

来源：

ANALYTICAL BIOCHEMISTRY | 2004年 / 329卷 / 02期

基金：

美国国家科学基金会; 美国国家航空航天局;

关键词：

biosensor; composite electrodes; aqueous sol-gels; carbon nanotubes; enzyme stability;

D O I：

10.1016/j.ab.2004.02.025

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new type of composite material based on carbon nanotubes and an aqueous sol-gel process has been developed. The electro-chemical characteristics of these composites were investigated and compared to composites made with an alkoxy silane sol-get process. The use of carbon nanotubes, as the conductive part of the composite, facilitated fast electron transfer rates. The feasibility of this type of composite for the development of biosensors was demonstrated using L-amino acid oxidase. The stability of the enzyme was increased when it was encapsulated in the aqueous sol-gel, and the sensor retained more that 50% of its response after 1 month of testing. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：247 / 252

页数：6

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