Signalling through C-type lectin receptors: shaping immune responses

被引：985

作者：

Geijtenbeek, Teunis B. H. ^{[1
]}

Gringhuis, Sonja I.

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 07期

关键词：

HUMAN DENDRITIC CELLS; NF-KAPPA-B; DENGUE VIRUS-INFECTION; GROWTH-FACTOR-BETA; CD8(+) T-CELLS; DC-SIGN; CUTTING EDGE; CYTOKINE PRODUCTION; MYELOID CELLS; IN-VIVO;

D O I：

10.1038/nri2569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates. Some CLRs can induce signalling pathways that directly activate nuclear factor-kappa B, whereas other CLRs affect signalling by Toll-like receptors. Dissecting these signalling pathways and their effects on host immune cells is essential to understand the molecular mechanisms involved in the induction of adaptive immune responses. In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches.

引用

页码：465 / 479

页数：15

共 106 条

[1] Cutting edge: Different toll-like receptor agonists instruct dendritic cells to induce distinct th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-fos [J].

Agrawal, S ;

Agrawal, A ;

Doughty, B ;

Gerwitz, A ;

Blenis, J ;

Van Dyke, T ;

Pulendran, B .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :4984-4989

[2] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[3] Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 [J].

An, Huazhang ;

Hou, Jin ;

Zhou, Jun ;

Zhao, Wei ;

Xu, Hongmei ;

Zheng, Yuejuan ;

Yu, Yizhi ;

Liu, Shuxun ;

Cao, Xuetao .

NATURE IMMUNOLOGY, 2008, 9 (05) :542-550

[4] SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production [J].

An, Huazhang ;

Zhao, Wei ;

Hou, Jin ;

Zhang, Yan ;

Xie, Yun ;

Zheng, Yuejuan ;

Xu, Hongmei ;

Qian, Cheng ;

Zhou, Jun ;

Yu, Yizhi ;

Liu, Shuxun ;

Feng, Gensheng ;

Cao, Xuetao .

IMMUNITY, 2006, 25 (06) :919-928

[5] Cutting edge: Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells [J].

Appelmelk, BJ ;

van Die, I ;

van Vliet, SJ ;

Vandenbroucke-Grauls, CMJE ;

Geijtenbeek, TBH ;

van Kooyk, Y .

JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :1635-1639

[6] Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells [J].

Bakker, ABH ;

Baker, E ;

Sutherland, GR ;

Phillips, JH ;

Lanier, LL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9792-9796

[7] Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells [J].

Barrett, Nora A. ;

Maekawa, Akiko ;

Rahman, Opu M. ;

Austen, K. Frank ;

Kanaoka, Yoshihide .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :1119-1128

[8] Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN [J].

Bergman, MP ;

Engering, A ;

Smits, HH ;

van Vliet, SJ ;

van Bodegraven, AA ;

Wirth, HP ;

Kapsenberg, ML ;

Vandenbroucke-Grauls, CMJE ;

van Kooyk, Y ;

Appelmelk, BJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (08) :979-990

[9] In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination [J].

Bonifaz, LC ;

Bonnyay, DP ;

Charalambous, A ;

Darguste, DI ;

Fujii, SI ;

Soares, H ;

Brimnes, MK ;

Moltedo, B ;

Moran, TM ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (06) :815-824

[10] DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes [J].

Bozzacco, Leonia ;

Trumpfheller, Christine ;

Siegal, Frederick P. ;

Mehandru, Saurabh ;

Markowitz, Martin ;

Carrington, Mary ;

Nussenzweig, Michel C. ;

Piperno, Angela Granelli ;

Steinman, Ralph M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (04) :1289-1294

← 1 2 3 4 5 6 7 8 9 10 →