Adsorption of charged macromolecules on mixed fluid membranes

被引：23

作者：

Harries, D

May, S

Ben-Shaul, A ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Phys Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fritz Haber Res Ctr, IL-91904 Jerusalem, Israel

[3] Univ Jena, Inst Mol Biol, D-07745 Jena, Germany

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2002年 / 208卷 / 1-3期

关键词：

macromolecules; electrostatic interactions; lipid membranes;

D O I：

10.1016/S0927-7757(02)00100-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The adsorption of charge rigid macromolecules, such as proteins from solution, on mixed (charged and neutral) lipid membranes is affected by several important factors. First, the mobile lipids in the membrane may rearrange, and demix locally to match the charge density of the apposed macromolecule, thus lowering the adsorption free energy. On the other hand, the (electrostatic) interaction between adsorbed macromolecules tends to lower the saturation coverage of the membrane. Additional factors, such as non-ideal lipid demixing or an elastic membrane response, enhanced by the presence of the charged macromolecules, may be at the base of the experimentally observed formation of high density protein domains and lateral macro-phase separation in lipid membranes. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：41 / 50

页数：10

共 40 条

[1]

ADAMSON AW, 1990, PHYSICAL CHEM SURFAC, pCH11

[2] EXTENSIVE SEGREGATION OF ACIDIC PHOSPHOLIPIDS IN MEMBRANES INDUCED BY PROTEIN-KINASE-C AND RELATED PROTEINS [J].