Healthy obesity

被引:80
作者
Wildman, Rachel P. [1 ]
机构
[1] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
关键词
body composition; cardiovascular disease; metabolic syndrome; obesity; BODY-MASS INDEX; VISCERAL FAT ACCUMULATION; METABOLIC RISK-FACTORS; HUMAN ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; UNCOMPLICATED OBESITY; MYOCARDIAL-INFARCTION; ADIPONECTIN LEVELS; ADIPOCYTE SIZE; LIVER-DISEASE;
D O I
10.1097/MCO.0b013e32832c6db7
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Purpose of review To introduce the healthy obese phenotype, characterized by favorable cardiometabolic risk factors despite excess adipose tissue. The epidemiology of the healthy obese phenotype is presented, including associated risk of cardiovascular disease (CVD), and potential biologic mechanisms which may give rise to the phenotype are discussed. Recent findings Although it appears that approximately 30% of obese individuals maintain healthy cardiometabolic profiles, little published data exist examining the healthy obese phenotype. The healthy obese do not appear to be at increased risk of incident CVD events compared with at-risk obese, and the location of adipose tissue and the metabolic characteristics of the fat in a given location, including the presence of ectopic fat and associated adipocytokine response, may give rise to the phenotype. Recent data also suggest that weight loss among healthy obese may adversely impact their favorable cardiometabolic profile. Summary A high prevalence of the healthy obese phenotype has been reported, and these individuals appear to be at no increased risk of CVD. Further research is needed into the mechanisms that allow these individuals to maintain low risk of CVD despite excess adiposity and appropriate weight loss recommendations for this group.
引用
收藏
页码:438 / 443
页数:6
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