The role of GLP-1 in the regulation of islet cell mass

被引：24

作者：

Bulotta, A ^{[1
]}

Farilla, L ^{[1
]}

Hui, HX ^{[1
]}

Perfetti, R ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Dept Med, Los Angeles, CA 90048 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2004年

关键词：

beta-cells; insulin; differentiation; regeneration and apoptosis; diabetes;

D O I：

10.1385/CBB:40:3S:065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucagon-like peptide-1 (GLP-1) is an incretin hormone capable of restoring euglycemia in glucose-intolerant subjects and improving glucose control in individuals with type 2 diabetes. Whether the antidiabetic properties of GLP-1 are exclusively the result of its acute postprandial action is being investigated. A GLP-1-dependent differentiation of pancreatic precursor cells into mature beta-cells has been proposed. In addition, GLP-1 has been shown to have antiapoptotic activity in cultured insulin-secreting cells and in an animal model in which diabetes occurs as a consequence of an excessive rate of beta-cell apoptosis. Studies from our laboratory, and others, lead us to propose that GLP-1 is a growth factor for pancreatic cells and it is a regulator of islet cell mass. The aim of this article is to review those reports that have emphasized the role of GLP-1 as a regulator of islet cell mass as well as its insulin secretory action.

引用

页码：65 / 77

页数：13

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