Association of Endogenous Sex Hormones With Diabetes and Impaired Fasting Glucose in Men

被引：78

作者：

Colangelo, Laura A. ^{[1
]}

Ouyang, Pamela ^{[2
]}

Liu, Kiang ^{[1
]}

Kopp, Peter ^{[3
]}

Golden, Sherita Hill ^{[2
,4
]}

Dobs, Adrian S. ^{[2
]}

Szklo, Moyses ^{[4
]}

Vaidya, Dhananjay ^{[2
]}

Cushman, Mary ^{[5
]}

Gapstur, Susan M. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[3] Northwestern Univ, Div Endocrinol Metab & Mol Med, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[5] Univ Vermont, Dept Med, Burlington, VT USA

来源：

DIABETES CARE | 2009年 / 32卷 / 06期

关键词：

INSULIN SENSITIVITY; ELDERLY-MEN; MALE-RATS; TESTOSTERONE; SECRETION; RESISTANCE; ANDROGENS; WOMEN;

D O I：

10.2337/dc08-2216

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

OBJECTIVE - To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men. RESEARCH DESIGN AND METHODS - A total of 3,156 African American, Non-Hispanic white, Hispanic, and Chinese-American men aged 45-84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis (MESA) were included. Odds ratios and 95% Cls for type 2 diabetes and IFG compared with normal fasting glucose for quartiles of hormones were estimated. RESULTS - After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone and sex hormone-binding globulin (SHBG) and positively with estradiol (E2). Dehydroepiandrosterone was positively associated with IFG but not with diabetes. Associations did not differ across ethnic groups. CONCLUSIONS - Regardless of obesity, total testosterone and SHBG were associated inversely and E2 was associated positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biological mechanisms. Diabetes Care 32:1049-1051, 2009

引用

页码：1049 / 1051

页数：3

共 14 条

[1]

Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men [J].