Early life antibiotic exposure affects pancreatic islet development and metabolic regulation

被引:28
作者
Li, Jiaying [1 ]
Yang, Kaiyuan [1 ]
Ju, Tingting [1 ]
Ho, Tracy [1 ]
McKay, Catharine A. [1 ]
Gao, Yanhua [1 ]
Forget, Shay K. [1 ]
Gartner, Stephanie R. [1 ]
Field, Catherine J. [1 ]
Chan, Catherine B. [1 ,2 ]
Willing, Benjamin P. [1 ]
机构
[1] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada
[2] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2H7, Canada
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
INTESTINAL ALKALINE-PHOSPHATASE; CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; BETA-CELL PROLIFERATION; HUMAN GUT MICROBIOTA; CHILDHOOD OVERWEIGHT; POSTNATAL-GROWTH; OBESITY; PERTURBATION; APOPTOSIS;
D O I
10.1038/srep41778
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Childhood antibiotic exposure has been recently linked with increased risk of metabolic disease later in life. A better understanding of this association would potentially provide strategies to reduce the childhood chronic disease epidemic. Therefore, we explored the underlying mechanisms using a swine model that better mimics human infants than rodents, and demonstrated that early life antibiotic exposure affects glucose metabolism 5 weeks after antibiotic withdrawal, which was associated with changes in pancreatic development. Antibiotics exerted a transient impact on postnatal gut microbiota colonization and microbial metabolite production, yet changes in the expression of key genes involved in short-chain fatty acid signaling and pancreatic development were detected in later life. These findings suggest a programming effect of early life antibiotic exposure that merits further investigation.
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页数:12
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共 77 条
  • [1] Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
    Ajslev, T. A.
    Andersen, C. S.
    Gamborg, M.
    Sorensen, T. I. A.
    Jess, T.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2011, 35 (04) : 522 - 529
  • [2] Bleach gel: A simple agarose gel for analyzing RNA quality
    Aranda, Patrick S.
    LaJoie, Dollie M.
    Jorcyk, Cheryl L.
    [J]. ELECTROPHORESIS, 2012, 33 (02) : 366 - 369
  • [3] Impact of Prematurity and Perinatal Antibiotics on the Developing Intestinal Microbiota: A Functional Inference Study
    Arboleya, Silvia
    Sanchez, Borja
    Solis, Gonzalo
    Fernandez, Nuria
    Suarez, Marta
    Hernandez-Barranco, Ana M.
    Milani, Christian
    Margolles, Abelardo
    de los Reyes-Gavilan, Clara G.
    Ventura, Marco
    Gueimonde, Miguel
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (05)
  • [4] Maternal Antibiotic-Induced Early Changes in Microbial Colonization Selectively Modulate Colonic Permeability and Inducible Heat Shock Proteins, and Digesta Concentrations of Alkaline Phosphatase and TLR-Stimulants in Swine Offspring
    Arnal, Marie-Edith
    Zhang, Jing
    Erridge, Clett
    Smidt, Hauke
    Lalles, Jean-Paul
    [J]. PLOS ONE, 2015, 10 (02):
  • [5] Early Changes in Microbial Colonization Selectively Modulate Intestinal Enzymes, but Not Inducible Heat Shock Proteins in Young Adult Swine
    Arnal, Marie-Edith
    Zhang, Jing
    Messori, Stefano
    Bosi, Paolo
    Smidt, Hauke
    Lalles, Jean-Paul
    [J]. PLOS ONE, 2014, 9 (02):
  • [6] The intestinal microbiome in early life: health and disease
    Arrieta, Marie-Claire
    Stiemsma, Leah T.
    Amenyogbe, Nelly
    Brown, Eric M.
    Finlay, Brett
    [J]. FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [7] Infant antibiotic exposure and the development of childhood overweight and central adiposity
    Azad, M. B.
    Bridgman, S. L.
    Becker, A. B.
    Kozyrskyj, A. L.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2014, 38 (10) : 1290 - 1298
  • [8] Association of Antibiotics in Infancy With Early Childhood Obesity
    Bailey, L. Charles
    Forrest, Christopher B.
    Zhang, Peixin
    Richards, Thomas M.
    Livshits, Alice
    DeRusso, Patricia A.
    [J]. JAMA PEDIATRICS, 2014, 168 (11) : 1063 - 1069
  • [9] Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota
    Bates, Jennifer M.
    Akerlund, Janie
    Mittge, Erika
    Guillemin, Karen
    [J]. CELL HOST & MICROBE, 2007, 2 (06) : 371 - 382
  • [10] The postnatal growth of the β-cell mass in pigs
    Bock, T
    Kyhnel, A
    Pakkenberg, B
    Buschard, K
    [J]. JOURNAL OF ENDOCRINOLOGY, 2003, 179 (02) : 245 - 252