Stereoselective synthesis of highly functionalised pyrrolidines via 1,3-dipolar cycloaddition reactions on a solid support.

被引：51

作者：

Hollinshead, SP

机构：

[1] Sphinx Pharmaceuticals, Division of Eli Lilly and Company, Durham, NC 27707

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(96)02147-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Resin bound 3-hydroxyacetophenone 2 was condensed (NaOMe/MeOH/THF) with aryl aldehydes to afford alpha,beta-unsaturated ketones 3a-e. Subsequent reaction with azomethine ylid 5 in the presence of LiBr/DBU provided pyrrolidines 6a-d. These were subsequently acylated and cleaved from the solid support to afford highly functionalised pyrrolidines 8a-d. Copyright (C) 1996 Elsevier Science Ltd

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页码：9157 / 9160

页数：4

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