Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on Testosterone Release from Rat Leydig Cells

被引：23

作者：

Hsia, Shih-Min ^{[1
,2
]}

Tseng, Yi-Wen ^{[1
]}

Wang, Shyi-Wu ^{[3
]}

Kuo, Yueh-Hsiung ^{[4
]}

Huang, Din-Wen ^{[1
]}

Wang, Paulus S. ^{[5
,6
]}

Chiang, Wenchang ^{[1
]}

机构：

[1] Natl Taiwan Univ, Grad Inst Food Sci & Technol, Ctr Food & Biomol, Coll Bioresources & Agr, Taipei 106, Taiwan

[2] Cardinal Tien Coll Healthcare & Management, Taipei 231, Taiwan

[3] Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan 333, Taiwan

[4] China Med Univ, Coll Pharm, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Dept Physiol, Taipei 112, Taiwan

[6] Taipei City Hosp, Dept Med Res & Educ, Taipei 103, Taiwan

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 05期

关键词：

adlay hulls; testosterone; Leydig cell; LUTEINIZING-HORMONE; IN-VITRO; INHIBITION; SECRETION; TESTIS; SEED; PROGESTERONE; LOCALIZATION; PITUITARY; MOUSE;

D O I：

10.1002/ptr.2706

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Adlay has been used as a traditional Chinese medicine for the treatment of many diseases. However, few studies have reported the effects of adlay seeds on the endocrine system. In the present study, the effects of methanol extracts of adlay hull (AHM) on testosterone synthesis were studied. Rat Leydig cells were incubated with different reagents including human chorionic gonadotropin, 8-bromo-adenosine-3',5'-cyclic monophosphate, forskolin, A23187, progesterone and androstenedione in the presence or absence of AHM. The rat anterior pituitary (AP) gland was treated with gonadotropin-releasing hormone (GnRH) in vitro in the presence or absence of AHM, and the concentrations of luteinizing hormone (LH) in the media were measured. AHM decreased testosterone release via the inhibition of (1) the PKA and PKC signal transduction pathways, (2) 17 beta-HSD enzyme activity in rat Leydig cells, and (3) in vitro GnRH-induced LH secretion. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：687 / 695

页数：9

共 30 条

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[Anonymous], PLANTA MED

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