The origins and the future of microfluidics

被引：7062

作者：

Whitesides, George M. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

NATURE | 2006年 / 442卷 / 7101期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05058

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The manipulation of fluids in channels with dimensions of tens of micrometres - microfluidics - has emerged as a distinct new field. Microfluidics has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology. But the field is still at an early stage of development. Even as the basic science and technological demonstrations develop, other problems must be addressed: choosing and focusing on initial applications, and developing strategies to complete the cycle of development, including commercialization. The solutions to these problems will require imagination and ingenuity.

引用

页码：368 / 373

页数：6

共 67 条

[1] Formation of dispersions using "flow focusing" in microchannels [J].

Anna, SL ;

Bontoux, N ;

Stone, HA .

APPLIED PHYSICS LETTERS, 2003, 82 (03) :364-366

[2] Miniaturised nucleic acid analysis [J].

Auroux, PA ;

Koc, Y ;

deMello, A ;

Manz, A ;

Day, PJR .

LAB ON A CHIP, 2004, 4 (06) :534-546

[3] Long-term monitoring of bacteria undergoing programmed population control in a microchemostat [J].

Balagaddé, FK ;

You, LC ;

Hansen, CL ;

Arnold, FH ;

Quake, SR .

SCIENCE, 2005, 309 (5731) :137-140

[4] Microfluidic single-mode laser using high-order Bragg grating and antiguiding segments [J].

Balslev, S ;

Kristensen, A .

OPTICS EXPRESS, 2005, 13 (01) :344-351

[5] Physics and applications of microfluidics in biology [J].

Beebe, DJ ;

Mensing, GA ;

Walker, GM .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 :261-286

[6] Microfluidics-based systems biology [J].

Breslauer, DN ;

Lee, PJ ;

Lee, LP .

MOLECULAR BIOSYSTEMS, 2006, 2 (02) :97-112

[7] A microfluidic 2x2 optical switch [J].

Campbell, K ;

Groisman, A ;

Levy, U ;

Pang, L ;

Mookherjea, S ;

Psaltis, D ;

Fainman, Y .

APPLIED PHYSICS LETTERS, 2004, 85 (25) :6119-6121

[8] Passively driven integrated microfluidic system for separation of motile sperm [J].

Cho, BS ;

Schuster, TG ;

Zhu, XY ;

Chang, D ;

Smith, GD ;

Takayama, S .

ANALYTICAL CHEMISTRY, 2003, 75 (07) :1671-1675

[9] Human neural stem cell growth and differentiation in a gradient-generating microfluidic device [J].

Chung, BG ;

Flanagan, LA ;

Rhee, SW ;

Schwartz, PH ;

Lee, AP ;

Monuki, ES ;

Jeon, NL .

LAB ON A CHIP, 2005, 5 (04) :401-406

[10] Nanofluidic channels with elliptical cross sections formed using a nonlithographic process [J].

Czaplewski, DA ;

Kameoka, J ;

Mathers, R ;

Coates, GW ;

Craighead, HG .

APPLIED PHYSICS LETTERS, 2003, 83 (23) :4836-4838

← 1 2 3 4 5 6 7 →