Analysis of one million base pairs of Neanderthal DNA

被引：429

作者：

Green, Richard E.

Krause, Johannes

Ptak, Susan E.

Briggs, Adrian W.

Ronan, Michael T.

Simons, Jan F.

Du, Lei

Egholm, Michael

Rothberg, Jonathan M.

Paunovic, Maja

Paeaebo, Svante

机构：

[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany

[2] 454 Life Sci, Branford, CT 06405 USA

[3] Croatian Acad Sci & Arts, Inst Quaternary Paleontol & Geol, HR-10000 Zagreb, Croatia

来源：

NATURE | 2006年 / 444卷 / 7117期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nature05336

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000- year- old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high- throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome- sequencing effort.

引用

页码：330 / 336

页数：7

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