Lateral gene transfer and the nature of bacterial innovation

被引:2623
作者
Ochman, H [1 ]
Lawrence, JG
Groisman, EA
机构
[1] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA
[2] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA
[3] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol, St Louis, MO 63110 USA
关键词
D O I
10.1038/35012500
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms. Horizontal gene transfer produces extremely dynamic genomes in which substantial amounts of DNA are introduced into and deleted from the chromosome. These lateral transfers have effectively changed the ecological and pathogenic character of bacterial species.
引用
收藏
页码:299 / 304
页数:6
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