Pancreatic cancer Hurdles in the engineering of CAR-based immunotherapies

被引：12

作者：

Abate-Daga, Daniel ^{[1
]}

Rosenberg, Steven A. ^{[1
]}

Morgan, Richard A. ^{[2
]}

机构：

[1] NCI, Surg Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[2] Bluebird Bio, Cambridge, MA USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 06期

关键词：

adoptive immunotherapy; PSCA; pancreatic cancer; chimeric antigen receptors (CAR); synthetic biology; ANTITUMOR-ACTIVITY; RECEPTORS;

D O I：

10.4161/onci.29194

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development of immunotherapies, and potential strategies to circumvent on-target/off-tumor toxicities.

引用

页数：3

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