Prognostic factors and survival rate of osteosarcoma: A single-institution study

被引：95

作者：

Faisham, Wan Ismail ^{[1
]}

Mat Saad, Arman Zaharil ^{[7
]}

Alsaigh, Laith N. ^{[1
]}

Nor Azman, Mat Z. ^{[1
]}

Kamarul Imran, Musa ^{[2
]}

Biswal, Biswa M. ^{[3
]}

Bhavaraju, Venkata M. K. ^{[3
]}

Salzihan, Md Salleh ^{[4
]}

Hasnan, Jaafar ^{[4
]}

Ezane, Aziz M. ^{[5
]}

Ariffin, Nasir ^{[6
]}

Norsarwany, Mohamad ^{[6
]}

Ziyadi, Mohamad G. ^{[8
]}

Wan Azman, Wan Sulaiman ^{[7
]}

Halim, Ahmad Sukari ^{[7
]}

Zulmi, Wan ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Orthopaed, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[2] Univ Sains Malaysia, Sch Med Sci, Dept Community Med, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[3] Univ Sains Malaysia, Sch Med Sci, Dept Radiat Therapy & Oncol, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[4] Univ Sains Malaysia, Sch Med Sci, Dept Pathol, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[5] Univ Sains Malaysia, Sch Med Sci, Dept Radiol, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[6] Univ Sains Malaysia, Sch Med Sci, Dept Pediat Oncol, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[7] Univ Sains Malaysia, Sch Med Sci, Reconstruct Sci Unit, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

[8] Univ Sains Malaysia, Sch Med Sci, Cardiothorac Unit, Hlth Campus, Kubang Kerian, Kelantan, Malaysia

来源：

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 13卷 / 02期

关键词：

extremity; osteosarcoma; prognosis; survival analysis; STUDY-GROUP PROTOCOLS; NEOADJUVANT CHEMOTHERAPY; NONMETASTATIC OSTEOSARCOMA; EXTREMITIES; INTERGROUP; EXPERIENCE; GRADE;

D O I：

10.1111/ajco.12346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Aim: Osteosarcoma is a highly malignant primary bone tumor. The study aim to evaluate the prognostic factors influencing the survival rate in our center. Methods: This was a retrospective cohort study of all patients treated between January 2005 and December 2010. Results: We included 163 patients with an age range of 6-59 years (median = 19). The median follow-up was 47 months (range 36-84). The overall survival in patients who completed chemotherapy and surgery (n = 117) was 72% at 2 years and 44% at 5 years. Histologically, 99 (85%) had osteoblastic, 6 (5%) had chondroblastic and 3 (2.5%) had telangiectatic osteosarcoma. Limb salvage surgery was performed in 80 (49%) and 41 (25%) underwent amputation. However, 46 patients (28%) underwent no surgical intervention and incomplete chemotherapy. In total, 38/79 patients had a good chemotherapy response. There was a significantly better survival rate for limb salvage versus amputation. Independent prognostic factors for survival are compliance to treatment and presence of lung metastasis. Conclusion: The overall survival of osteosarcoma patients was influenced by the presence of pulmonary metastases and compliance to treatment. Histological subtype, different chemotherapy regimens and histological necrosis after chemotherapy did not significantly influence survival. The patients who did not complete treatment had significantly poorer survival.

引用

页码：E104 / E110

页数：7

共 18 条

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Does Increased Rate of Limb-sparing Surgery Affect Survival in Osteosarcoma? [J].