Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments

被引：94

作者：

Cunha, Carla ^{[1
,2
]}

Angelucci, Andrea ^{[3
]}

D'Antoni, Angela ^{[1
,4
]}

Dobrossy, Mate D. ^{[5
]}

Dunnett, Stephen B. ^{[5
]}

Berardi, Nicoletta ^{[3
,6
]}

Brambilla, Riccardo ^{[1
]}

机构：

[1] Ist Sci San Raffaele, I-20132 Milan, Italy

[2] Univ Porto, Fac Ciencias, Oporto, Portugal

[3] CNR, Inst Neurosci, I-56100 Pisa, Italy

[4] Univ Milan, I-20122 Milan, Italy

[5] Sch Biosci, Cardiff, S Glam, Wales

[6] Univ Florence, Dept Psychol, Florence, Italy

来源：

NEUROBIOLOGY OF DISEASE | 2009年 / 33卷 / 03期

基金：

英国医学研究理事会;

关键词：

BDNF; Spatial learning; Passive avoidance; Short-term memory; LONG-TERM-POTENTIATION; HIGH-FREQUENCY STIMULATION; HIPPOCAMPAL-NEURONS; SYNAPTIC-TRANSMISSION; ADULT HIPPOCAMPUS; PROTEIN-SYNTHESIS; ENDOGENOUS BDNF; DEFICIENT MICE; MUTANT MICE; MAP KINASE;

D O I：

10.1016/j.nbd.2008.11.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the (alpha CaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：358 / 368

页数：11

共 80 条

[1]

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor [J].