Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

被引：386

作者：

Hordijk, PL ^{[1
]}

tenKlooster, JP ^{[1
]}

vanderKammen, RA ^{[1
]}

Michiels, F ^{[1
]}

Oomen, LCJM ^{[1
]}

Collard, JG ^{[1
]}

机构：

[1] NETHERLANDS CANC INST,DIV CELL BIOL,NL-1066 CX AMSTERDAM,NETHERLANDS

来源：

SCIENCE | 1997年 / 278卷 / 5342期

关键词：

D O I：

10.1126/science.278.5342.1464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin-Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepatocyte growth factor-induced scattering by increasing E-cadherin-mediated cell-cell adhesion accompanied by actin polymerization at cell-cell contacts. In Ras-transformed MDCK cells, expression of Tiam1 or RacV12 restored E-cadherin-mediated adhesion, resulting in phenotypic reversion and loss of invasiveness. These data suggest an invasion-suppressor role for Tiam1 and Rac in epithelial cells.

引用

页码：1464 / 1466

页数：3

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