Neutrophil Extracellular Traps: A Strategic Tactic to Defeat Pathogens with Potential Consequences for the Host

被引：72

作者：

Medina, Eva ^{[1
]}

机构：

[1] Helmholtz Ctr Infect Res, Infect Immunol Res Grp, Dept Microbial Pathogenesis, DE-38124 Braunschweig, Germany

来源：

JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 03期

关键词：

Neutrophils; Neutrophil extracellular traps; Pathogens; Antimicrobial mechanisms; Mast cell extracellular traps; ETosis; Reactive oxygen radicals; GROUP-A STREPTOCOCCUS; MAST-CELLS; PREECLAMPSIA; PNEUMONIAE; IMMUNITY; ESCAPE; ALLOWS; NETS;

D O I：

10.1159/000203699

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent investigations have highlighted new roles for neutrophils in the biology of infection and inflammation. Neutrophils are one of the main players in the innate immune system and actively contribute to host defense by killing pathogens. Added to their ability to eliminate microorganisms by phagocytosis, neutrophils can also kill microbes by capturing them in extracellular structures consisting of granule proteins and DNA called neutrophil extracellular traps (NETs). This review summarizes the recent advancements regarding the structure, production and biological relevance of NETs. Copyright (C) 2009 S. Karger AG, Basel

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页码：176 / 180

页数：5

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