Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation

被引：14

作者：

Huang, Yuchuan ^{[1
]}

Shan, Juan ^{[1
]}

Wang, Chuan'en ^{[2
]}

Ma, Jie ^{[3
]}

Li, Dan ^{[4
]}

Li, Li ^{[1
]}

Li, Shengfu ^{[1
]}

Li, Youping ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Transplant Engn & Immunol, W China Hosp, Minist Hlth, Chengdu 610041, Peoples R China

[2] Chengdu Phys Educ Univ, Sports Med Dept, Chengdu, Peoples R China

[3] Second Tradit Chinese Hosp Sichuan, Acupuncture Rehabil Dept, Sichuan, Peoples R China

[4] Sichuan Univ, Dept Physiol, W China Sch Preclin & Forens Med, Chengdu 610041, Peoples R China

来源：

TRANSPLANT IMMUNOLOGY | 2009年 / 20卷 / 03期

关键词：

Ischemic preconditioning; Transplantation; Ischemia reperfusion injury; DONOR LIVER-TRANSPLANTATION; BYPASS GRAFT-SURGERY; NITRIC-OXIDE; ISCHEMIA/REPERFUSION INJURY; LUNG PRESERVATION; INFARCT SIZE; OXYGEN; MECHANISMS; NITROGLYCERIN; MODULATION;

D O I：

10.1016/j.trim.2008.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Organ transplantation is the only choice for treatment of end-stage disease. The ischemia reperfusion injury(I/RI) occurring after cold ischemia is an unavoidable injury during transplantation, which is also one of the main causes of graft failure. Multiple mechanisms have been postulated to explain tissue injury that occurs after I/RI. It is well-known that ischemic preconditioning (IPC), a short period of ischemia followed by reperfusion, arouses the endogenous mechanism of protection against a sustained ischemic insult. Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation? (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：127 / 131

页数：5

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