Notch signaling in Drosophila long-term memory formation

被引:88
作者
Ge, XC
Hannan, F
Xie, ZL
Feng, CH
Tully, T
Zhou, HM
Xie, ZP
Zhong, Y [1 ]
机构
[1] Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[3] JoeKai Inc, Beijing 100084, Peoples R China
关键词
D O I
10.1073/pnas.0403497101
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, neither learning nor early memory were affected. Furthermore, induced overexpression of a wild-type (normal) N transgene specifically enhanced LTM formation. These experiments demonstrate that N signaling contributes to LTM formation in the Drosophila adult brain.
引用
收藏
页码:10172 / 10176
页数:5
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