Current trends in needle-free jet injection: an update

被引:64
作者
Barolet, Daniel [1 ,2 ]
Benohanian, Antranik [3 ]
机构
[1] RoseLab Skin Opt Res Lab, 3333,100th Ave, Laval, PQ H7T 0G3, Canada
[2] McGill Univ, Dept Med, MUHC Dermatol Serv, Montreal, PQ, Canada
[3] Univ Montreal, CHUM Serv Dermatol, Montreal, PQ, Canada
关键词
needle free; injector; jet injection; xylocaine; triamcinolone; PDT; TOXIN TYPE-A; BASAL-CELL CARCINOMA; BOTULINUM-TOXIN; PALMAR HYPERHIDROSIS; PHOTODYNAMIC THERAPY; FREE ANESTHESIA; NAIL PSORIASIS; TRIAMCINOLONE ACETONIDE; INTRALESIONAL TREATMENT; PLANTAR HYPERHIDROSIS;
D O I
10.2147/CCID.S162724
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100227 [皮肤病学];
摘要
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use. Methods: A review of the literature was performed with no limits placed on publication date. Results: Needleless injectors not only reduce pain during drug delivery but also confine the drug more evenly in the dermis. Understanding skin properties of the injection site is a key factor to obtain optimal results as well as setting the right parameters of the jet injector. Until the advent of disposable jet injectors/cartridges, autoclaving of the injector remains the only reliable method to eliminate the risk of infection. Needle-free intradermal injection using corticosteroids and/or local anesthetics is well documented with promising indications being developed. Limitations: Limitations of the review include low-quality evidence, small sample sizes, varying treatment parameters, and publication bias. Conclusion: New developments may help reconsider the use of jet injection technology. Future studies should focus on measurable optimized parameters to insure a safe and effective outcome.
引用
收藏
页码:231 / 238
页数:8
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