Melan-A/MART-1-specific CD8 T cells: from thymus to tumor

被引：43

作者：

Pittet, MJ ^{[1
]}

Zippelius, A ^{[1
]}

Valmori, D ^{[1
]}

Speiser, DE ^{[1
]}

Cerottini, JC ^{[1
]}

Romero, P ^{[1
]}

机构：

[1] CHU Vaudois, Univ Hosp, Div Clin Oncoimmunol, Ludwig Inst Canc Res, CH-1011 Lausanne, Switzerland

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 07期

关键词：

D O I：

10.1016/S1471-4906(02)02244-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers; incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known,this is the only one directly accessible to analysis in healthy individuals.

引用

页码：325 / 328

页数：4

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