CANCER The nuances of therapy

被引：49

作者：

Ellis, Lee M. ^{[1
,2
]}

Reardon, David A. ^{[3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumour Ctr, Durham, NC 27710 USA

来源：

NATURE | 2009年 / 458卷 / 7236期

关键词：

D O I：

10.1038/458290a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study.

引用

页码：290 / 292

页数：3

共 12 条

[1] HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion [J].

Du, Rose ;

Lu, Kan V. ;

Petritsch, Claudia ;

Liu, Patty ;

Ganss, Ruth ;

Passegue, Emmanuelle ;

Song, Hanqiu ;

VandenBerg, Scott ;

Johnson, Randall S. ;

Werb, Zena ;

Bergers, Gabriele .

CANCER CELL, 2008, 13 (03) :206-220

[2] Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy [J].

Ebos, John M. L. ;

Lee, Christina R. ;

Christensen, James G. ;

Mutsaers, Anthony J. ;

Kerbel, Robert S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :17069-17074

[3] Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis [J].

Ebos, John M. L. ;

Lee, Christina R. ;

Cruz-Munoz, William ;

Bjarnason, Georg A. ;

Christensen, James G. ;

Kerbel, Robert S. .

CANCER CELL, 2009, 15 (03) :232-239

[4] VEGF-targeted therapy: mechanisms of anti-tumour activity [J].

Ellis, Lee M. ;

Hicklin, Daniel J. .

NATURE REVIEWS CANCER, 2008, 8 (08) :579-591

[5] Sorafenib in advanced clear-cell renal-cell carcinoma [J].

Escudier, Bernard ;

Eisen, Tim ;

Stadler, Walter M. ;

Szczylik, Cezary ;

Oudard, Stephane ;

Siebels, Michael ;

Negrier, Sylvie ;

Chevreau, Christine ;

Solska, Ewa ;

Desai, Apurva A. ;

Rolland, Frederic ;

Demkow, Tomasz ;

Hutson, Thomas E. ;

Gore, Martin ;

Freeman, Scott ;

Schwartz, Brian ;

Shan, Minghua ;

Simantov, Ronit ;

Bukowski, Ronald M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :125-134

[6] Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene [J].

Ferrara, N ;

CarverMoore, K ;

Chen, H ;

Dowd, M ;

Lu, L ;

OShea, KS ;

PowellBraxton, L ;

Hillan, KJ ;

Moore, MW .

NATURE, 1996, 380 (6573) :439-442

[7] Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE) [J].

Grothey, Axel ;

Sugrue, Mary M. ;

Purdie, David M. ;

Dong, Wei ;

Sargent, Daniel ;

Hedrick, Eric ;

Kozloff, Mark .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) :5326-5334

[8]

KOPETZ S, 2009, P 2009 GASTR CANC S, P292

[9] Autocrine VEGF signaling is required for vascular homeostasis [J].

Lee, Sunyoung ;

Chen, Tom T. ;

Barber, Chad L. ;

Jordan, Maria C. ;

Murdock, Jared ;

Desai, Sharina ;

Ferrara, Napoleone ;

Nagy, Andras ;

Roos, Kenneth P. ;

Iruela-Arispe, M. Luisa .

CELL, 2007, 130 (04) :691-703

[10] Sorafenib in advanced hepatocellular carcinoma [J].

Llovet, Josep M. ;

Ricci, Sergio ;

Mazzaferro, Vincenzo ;

Hilgard, Philip ;

Gane, Edward ;

Blanc, Jean-Frederic ;

Cosme de Oliveira, Andre ;

Santoro, Armando ;

Raoul, Jean-Luc ;

Forner, Alejandro ;

Schwartz, Myron ;

Porta, Camillo ;

Zeuzem, Stefan ;

Bolondi, Luigi ;

Greten, Tim F. ;

Galle, Peter R. ;

Seitz, Jean-Francois ;

Borbath, Ivan ;

Haussinger, Dieter ;

Giannaris, Tom ;

Shan, Minghua ;

Moscovici, Marius ;

Voliotis, Dimitris ;

Bruix, Jordi .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :378-390

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