Antimicrobial resistance among urinary tract infection (UTI) isolates in Europe: results from the SENTRY Antimicrobial Surveillance Program 1997

被引:41
作者
Fluit, AC
Jones, ME
Schmitz, FJ
Acar, J
Gupta, R
Verhoef, J
机构
[1] Univ Utrecht Hosp, Eijkman Winkler Inst Microbiol Infect Dis & Infla, NL-3508 GA Utrecht, Netherlands
[2] Hop St Joseph, Dept Clin Microbiol, F-75674 Paris, France
[3] Bristol Myers Squibb Co, Princeton, NJ USA
来源
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 2000年 / 77卷 / 02期
关键词
antibiotic; resistance; surveillance; urinary tract infection;
D O I
10.1023/A:1002003123629
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The SENTRY Antimicrobial Surveillance Program was established to monitor the occurrence and antimicrobial susceptibility of bacterial pathogens via an international network of sentinel hospitals. Twenty European hospitals referred a total of 887 urinary tract infection (UTI) isolates to the European SENTRY reference laboratory during the period October-December 1997. Ninety percent of the referred species were represented by Escherichia coli (52%), Enterococcus spp. (12%), Klebsiella spp. (7%), Proteus spp. (7%), Pseudomonas aeruginosa (7%), and Enterobacter spp. (5%). The susceptibility of E. coli isolates to penicillins was less than 60%, while almost all of the isolates were susceptible to piperacillin/tazobactam (98% susceptibility), cephalosporins (98%), and carbapenems (100%). Amikacin was the best aminoglycoside (99.8% susceptibility). The susceptibility to quinolones was only 88-89%, with highest levels of resistance observed for isolates from Portugal, Italy, England, The Netherlands, and some centers in France, Spain, and Poland. The susceptibility of Klebsiella spp. to the newer generations of cephalosporins was 82-95% and to the carbapenems 100%. Amikacin was again the best aminoglycoside (94% susceptibility). The susceptibility of Enterobacter spp. to any ss-lactam antibiotic was poor, except for the carbapenems (100% susceptibility) and cefepime (90% susceptibility), while the susceptibility to aminoglycosides was 80-89%. Proteus spp. showed complete susceptibility to cefepime, ceftriaxone, the carbapenems, and piperacillin/tazobactam, while the susceptibility of P. aeruginosa isolates was poor, with best results for the carbapenems (susceptibility 89%), piperacillin/tazobactam (susceptibility 84%), and amikacin and ticarcillin (susceptibility to both 80%). Enterococcus spp. showed the highest susceptibility to vancomycin (98%), teicoplanin (98%), and ampicillin (94%).
引用
收藏
页码:147 / 152
页数:6
相关论文
共 18 条
[3]   EPIDEMIOLOGY OF DRUG-RESISTANCE - IMPLICATIONS FOR A POSTANTIMICROBIAL ERA [J].
COHEN, ML .
SCIENCE, 1992, 257 (5073) :1050-1055
[4]   Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993-1995 [J].
Cornaglia, G ;
Ligozzi, M ;
Mazzariol, A ;
Valentini, M ;
Orefici, G ;
Fontana, R .
EMERGING INFECTIOUS DISEASES, 1996, 2 (04) :339-342
[5]   Drug therapy - Antimicrobial-drug resistance [J].
Gold, HS ;
Moellering, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (19) :1445-1453
[6]  
GRUNEBERG RN, 1994, J ANTIMICROB CHEMOTH, V33, P1
[7]   URINARY-TRACT INFECTIONS IN WOMEN - DIAGNOSIS AND TREATMENT [J].
JOHNSON, JR ;
STAMM, WE .
ANNALS OF INTERNAL MEDICINE, 1989, 111 (11) :906-917
[8]  
Jones Ronald N., 1996, American Journal of Medicine, V100, p3S, DOI 10.1016/S0002-9343(96)00102-7
[9]  
LEQCLERC R, 1997, CLIN INFECT DIS S1, V24, pS80
[10]   Antimicrobial resistance among organisms causing urinary tract infections [J].
Marco, CA ;
Parker, K .
ACADEMIC EMERGENCY MEDICINE, 1997, 4 (02) :159-160