Apoptotic and proliferation indexes in primary superficial bladder tumors

被引：18

作者：

Gonzalez-Campora, Ricardo

Davalos-Casanova, Guillermo

Beato-Moreno, Antonio

Luque, Rafael J.

Alvarez-Kindelan, Jose

Requena, Maria J.

Montironi, Rodolfo

Lopez-Beltran, Antonio

机构：

[1] Virgen Macarena Univ Hosp, Dept Pathol, Seville 41009, Spain

[2] Univ Seville, Sch Med, Seville, Spain

[3] San Carlos Mil Hosp, Dept Urol, San Fernando De Henares, Spain

[4] Univ Seville, Dept Stat & Operat Res, Seville, Spain

[5] Univ Hosp Jaen, Dept Pathol, Jaen, Spain

[6] Reina Sofia Univ Hosp, Dept Urol, Cordoba, Spain

[7] Reina Sofia Univ Hosp, Dept Pathol, Cordoba, Spain

[8] Univ Cordoba, Sch Med, Cordoba, Spain

[9] Univ Politecn Marche Reg, Inst Pathol Anat & Histopathol, Ancona, Italy

来源：

CANCER LETTERS | 2006年 / 242卷 / 02期

关键词：

bladder cancer; apoptosis; Ki-67;

D O I：

10.1016/j.canlet.2005.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Whether apoptotic index [AI] and/or Ki-67 labeling index [Ki-67LI] add prognostic information in bladder cancer remains unclear. Mean AI and Ki-67 LI increased with grade and stage in 147 superficial bladder tumors. AI (> 1.7%) correlated with tumor size, grade and proliferation. Ki-67 LI (> 10%) correlated with higher grade and stage. Tumor size and Ki-67 LI were independent predictors of disease-free and progression-free survival, respectively. Tumor size, patient's age and tumor's recurrence predicted overall survival. We conclude that conventional clinical parameters and Ki-67 LI define risk groups of bladder tumors, while AI has limited value. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：266 / 272

页数：7

共 29 条

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