The 5-HT1A antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine

被引：20

作者：

Carey, R

Damianopoulos, E

DePalma, G

机构：

[1] VA Med Ctr, Res & Dev 151, Syracuse, NY 13210 USA

[2] SUNY Hlth Sci Ctr, Syracuse, NY 13210 USA

来源：

BRAIN RESEARCH | 2000年 / 862卷 / 1-2期

关键词：

cocaine; locomotion; 5-HT1A receptors; WAY; 100635; dopamine;

D O I：

10.1016/S0006-8993(00)02084-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cocaine treatments of 2.5, 5.0, 10.0 and 15.0 mg/kg induced dose-dependent increases in locomotor behavior. This cocaine-induced increase in locomotion was blocked if the animals were administered the selective 5-HT1A antagonist, WAY 100635 (0.4 mg/kg) prior to the cocaine treatment. The 0.4-mg/kg dose of WAY 100635 did not affect locomotor behavior or alter cocaine availability in brain. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：242 / 246

页数：5

共 20 条

[1] Neuropharmacological mechanisms of drug reward: Beyond dopamine in the nucleus accumbens [J].