Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3

被引：48

作者：

Hosokawa, Hiroyuki

Kimura, Motoko Y.

Shinnakasu, Ryo

Suzuki, Akane

Miki, Takako

Koseki, Haruhiko

van Lohuizen, Maarten

Yamashita, Masakatsu

Nakayama, Toshinori

机构：

[1] Chiba Univ, Dept Immunol, Grad Sch Med, Chuo Ku, Chiba 2608670, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Dev Biol Lab, Yokohama, Kanagawa, Japan

[3] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF IMMUNOLOGY | 2006年 / 177卷 / 11期

关键词：

D O I：

10.4049/jimmunol.177.11.7656

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The Polycomb group (PcG) gene products regulate the maintenance of the homeobox gene expression in Drosophila and vertebrates and also the cell cycle progression in thymocytes and Th2 cell differentiation in mature T cells. We herein studied the role of PcG gene bmi-1 product in Th1/Th2 cell differentiation and found that Bmi-1 facilitates Th2 cell differentiation in a Ring finger-dependent manner. Biochemical studies indicate that Bmi-1 interacts with GATA3 in T cells, which is dependent on the Ring finger of Bmi-1. The overexpression of Bmi-1 resulted in a decreased ubiquitination and an increased protein stability of GATA3. In bmi-1-deficient Th cells, the levels of Th2 cell differentiation decreased as the degradation and ubiquitination on GATA3 increased. Therefore, Bmi-1 plays a crucial role in the control of Th2 cell differentiation in a Ring finger-dependent manner by regulating GATA3 protein stability. The Journal of Immunology, 2006, 177: 7656-7664.

引用

页码：7656 / 7664

页数：9

共 52 条

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