A crossover, add-on trial of talampanel in patients with refractory partial seizures

被引：86

作者：

Chappell, AS ^{[1
]}

Sander, JW

Brodie, MJ

Chadwick, D

Lledo, A

Zhang, D

Bjerke, J

Kiesler, GM

Arroyo, S

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

[2] UCL, Dept Clin & Expt Epilepsy, London WC1E 6BT, England

[3] UCL, Inst Neurol, London WC1E 6BT, England

[4] Univ Liverpool, Walton Hosp, Dept Med & Therapeut, Epilepsy Unit, Liverpool L69 3BX, Merseyside, England

[5] Hosp Clin Barcelona, Epilepsy Unit, Barcelona, Spain

来源：

NEUROLOGY | 2002年 / 58卷 / 11期

关键词：

D O I：

10.1212/WNL.58.11.1680

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events.

引用

页码：1680 / 1682

页数：3

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