A model diagram layout extension for SBML

被引:20
作者
Gauges, Ralph [1 ]
Rost, Ursula [1 ]
Sahle, Sven [1 ]
Wegner, Katja [1 ]
机构
[1] EML Res, D-69118 Heidelberg, Germany
关键词
D O I
10.1093/bioinformatics/btl195
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Since the knowledge about processes in living cells is increasing, modelling and simulation techniques are used to get new insights into these complex processes. During the last few years, the SBML file format has gained in popularity and support as a means of exchanging model data between the different modelling and simulation tools. In addition to specifying the model as a set of equations, many modern modelling tools allow the user to create and to interact with the model in the form of a reaction graph. Unfortunately, the SBML file format does not provide for the storage of this graph data along with the mathematical description of the model. Results: Therefore, we developed an extension to the SBML file format that makes it possible to store such layout information which describes position and size of objects in the graphical representation. Availability: The complete specification can be found on (http://projects.villa-bosch.de/bcb/sbml/ (SBML Layout Extension documentation, 2005). Additionally, a complete implementation exists as part of libSBML (2006, http://www.sbml.org/software/libsbml/).
引用
收藏
页码:1879 / 1885
页数:7
相关论文
共 12 条
[1]  
BATIK, BATIK SVG TOOLKIT
[2]  
Finney A, 2003, BIOCHEM SOC T, V31, P1472
[3]   The systems biology markup language (SBML):: a medium for representation and exchange of biochemical network models [J].
Hucka, M ;
Finney, A ;
Sauro, HM ;
Bolouri, H ;
Doyle, JC ;
Kitano, H ;
Arkin, AP ;
Bornstein, BJ ;
Bray, D ;
Cornish-Bowden, A ;
Cuellar, AA ;
Dronov, S ;
Gilles, ED ;
Ginkel, M ;
Gor, V ;
Goryanin, II ;
Hedley, WJ ;
Hodgman, TC ;
Hofmeyr, JH ;
Hunter, PJ ;
Juty, NS ;
Kasberger, JL ;
Kremling, A ;
Kummer, U ;
Le Novère, N ;
Loew, LM ;
Lucio, D ;
Mendes, P ;
Minch, E ;
Mjolsness, ED ;
Nakayama, Y ;
Nelson, MR ;
Nielsen, PF ;
Sakurada, T ;
Schaff, JC ;
Shapiro, BE ;
Shimizu, TS ;
Spence, HD ;
Stelling, J ;
Takahashi, K ;
Tomita, M ;
Wagner, J ;
Wang, J .
BIOINFORMATICS, 2003, 19 (04) :524-531
[4]  
HUCKA M, 2005, SYSTEMS BIOL MARKUP
[5]  
KARP PD, 1994, 3 INT C BIOINF GEN R, P207
[6]   Using process diagrams for the graphical representation of biological networks [J].
Kitano, H ;
Funahashi, A ;
Matsuoka, Y ;
Oda, K .
NATURE BIOTECHNOLOGY, 2005, 23 (08) :961-966
[7]   Molecular interaction maps of bioregulatory networks: A general rubric for systems biology [J].
Kohn, KW ;
Aladjem, MI ;
Weinstein, JN ;
Pommier, Y .
MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (01) :1-13
[8]  
SAURO H, 2006, JDESIGNER SBML ANNOT
[9]  
SCHILLING CH, 1999, METABOLIC PATHWAY AN
[10]  
SCHREIBER F, 2002, SILICO BIOL, V6, P59