The enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene

被引：52

作者：

Wilting, Jos ^{[1
]}

Janssen, Michele ^{[1
]}

Muller, Christian ^{[1
]}

Vogt, Dieter ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Lab Homogeneous Catalysis, NL-5600 MB Eindhoven, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 35期

关键词：

ASYMMETRIC HYDROCYANATION; HYDROGEN-CYANIDE; ORGANOMETALLIC COMPOUNDS; MECHANISTIC ASPECTS; STEREOCHEMISTRY; ALKENES; OLEFINS; HYDROFORMYLATION;

D O I：

10.1021/ja064378u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On the basis of deuterium labeling experiments and an equal 1,2-/1,4-product distribution, the reductive elimination of the product has been established to be the enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene. This could be achieved by successfully exploiting the rather unique features of this reaction: identical product formation for 1,2- and 1,4-addition, cis addition over the diene, and high enantiomeric excess. Copyright © 2006 American Chemical Society.

引用

页码：11374 / 11375

页数：2

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