BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion?

被引：30

作者：

Cameselle-Teijeiro, Jose ^{[1
]}

Abdulkader, Ihab ^{[1
]}

Perez-Becerra, Raquel ^{[1
]}

Vazquez-Boquete, Angel ^{[1
]}

Alberte-Lista, Lara ^{[2
]}

Ruiz-Ponte, Clara ^{[3
]}

Forteza, Jeronimo ^{[1
]}

Sobrinho-Simoes, Manuel ^{[4
,5
,6
]}

机构：

[1] Univ Santiago de Compostela, Clin Univ Hosp, Galician Hlth Serv, Dept Pathol, Santiago De Compostela 15706, Spain

[2] Gen Hosp Vigo, Galician Hlth Serv, Dept Pathol, Vigo 36204, Spain

[3] Univ Santiago de Compostela, CIBER ER, Genom Med Grp, Galician Publ Fdn Genom Med, Santiago De Compostela 15706, Spain

[4] Univ Porto, Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal

[5] Univ Porto, Fac Med, Dept Pathol, P-4200 Oporto, Portugal

[6] Hosp Sao Joao, Dept Pathol, P-4200 Oporto, Portugal

来源：

HUMAN PATHOLOGY | 2009年 / 40卷 / 07期

关键词：

Solid cell nests; Papillary carcinoma; BRAF gene; Microcarcinoma; Thyroid; MUCOEPIDERMOID CARCINOMA; HASHIMOTOS-THYROIDITIS; LYMPHOCYTIC THYROIDITIS; P63; EXPRESSION; HYPOTHESIS; CANCER; METAPLASIA; ORIGIN; GLAND;

D O I：

10.1016/j.humpath.2008.11.015

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

We describe a case of solid cell nest hyperplasia associated with papillary thyroid carcinoma in a 48-year-old man with goiter. The entire gland was examined; in I section, the cells of I solid cell nest were in close contact with a follicular variant of papillary microcarcinoma. A second follicular variant of papillary microcarcinoma, 1 follicular adenoma, hyperplastic nodules, and some lymphoid aggregates were also found. Scattered p63-positive cells were found in the second papillary microcarcinoma. After microdissection, the same BRAF(V600E) mutation was found both in a pool of 5, solid cell nests and in the adjacent papillary microcarcinoma. BRAF(V600E) mutation and the previously unreported BRAF(G593D) mutation along with p.G606G silent change were found in the second papillary microcarcinoma, but no mutations were detected in the follicular adenoma or in the 2 other pools of solid cell nests screened for BRAF gene mutations. These findings Support a histogenetic link between the main cells of solid cell nests and papillary thyroid carcinoma, and suggest solid cell nest hyperplasia as a precursor lesion of papillary thyroid carcinoma. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1029 / 1035

页数：7

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