Effects of nematode infection on sensitivity to intestinal distension: Role of tachykinin NK2 receptors

被引：58

作者：

McLean, PG ^{[1
]}

Picard, C ^{[1
]}

GarciaVillar, R ^{[1
]}

More, J ^{[1
]}

Fioramonti, J ^{[1
]}

Bueno, L ^{[1
]}

机构：

[1] INRA,DEPT PHARMACOL TOXICOL,F-31931 TOULOUSE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 337卷 / 2-3期

关键词：

intestinal distension; visceral hyperalgesia; visceral nociception; mast cell; tachykinin; tachykinin NK2 receptor;

D O I：

10.1016/S0014-2999(97)01275-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Distension of the rat intestine causes a depressor response which is predictive of nociception. This study investigated the effects of previous infection with Nippostrongylus (N.) brasiliensis on the sensitivity to intestinal distension and the role of tachykinin NK2 receptors. The tachykinin NK2 receptor antagonist, SR48968 (S)-N-methyl-N[4-(4-acetylamico-3-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl]benzamide) inhibited the nociceptive response (ED50 = 0.7 mg/kg) in control rats. In post-N. brasiliensis-infected rats sensitivity to intestinal distension was increased which was accompanied by all increase in the apparent potency value of SR48968 (ED50 = 0.1 mg/kg). The hypersensitivity was limited to areas of hypermastocytosis. It is concluded that the post-inflammatory changes that occur in post-infected rats increase visceral sensitivity and the apparent potency of tachykinin NK2 receptor antagonists. (C) 1997 Elsevier Science B.V.

引用

页码：279 / 282

页数：4

共 18 条

[1] MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER [J].