A rapid and reversible change in dopamine transporters induced by methamphetamine

被引：44

作者：

Fleckenstein, AE

Metzger, RR

Gibb, JW

Hanson, GR

机构：

[1] Dept. of Pharmacology and Toxicology, 112 Skaggs Hall, University of Utah, Salt Lake City

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 323卷 / 2-3期

关键词：

methamphetamine; dopamine transporter; free radical;

D O I：

10.1016/S0014-2999(97)00148-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Because high doses of methamphetamine promote free radical formation, and striatal dopamine transporters are rapidly inactivated by oxidative events, we determined the effect of a single high dose of methamphetamine on dopamine transporter activity in striatal synaptosomes. One hour after methamphetamine administration, dopamine uptake decreased by 48%. This dramatic decline was totally reversed by 24 h after treatment. These findings suggest that methamphetamine reversibly decreases dopamine transporter activity by oxidative mechanisms.

引用

页码：R9 / R10

页数：2

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