The role of 11β-hydroxysteroid activity in the metabolic syndrome:: lessons learned from the animal model

被引:7
作者
Dötsch, J [1 ]
Rascher, W [1 ]
机构
[1] Univ Erlangen Nurnberg, Klin Kinder & Jugendliche, D-91054 Erlangen, Germany
关键词
D O I
10.1530/eje.0.1460603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In summary, we learn from the exciting study on 11β-HSD1 transgenic mice that tissue-specific glucocorticoid-dependent adipocyte pathways have a major impact on systemic metabolism and may provide a possible new target for the treatment of visceral obesity and the metabolic syndrome in humans.
引用
收藏
页码:603 / 605
页数:3
相关论文
共 16 条
[1]   GROWTH INUTERO, BLOOD-PRESSURE IN CHILDHOOD AND ADULT LIFE, AND MORTALITY FROM CARDIOVASCULAR-DISEASE [J].
BARKER, DJP ;
OSMOND, C ;
GOLDING, J ;
KUH, D ;
WADSWORTH, MEJ .
BRITISH MEDICAL JOURNAL, 1989, 298 (6673) :564-567
[2]   The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11β-hydroxysteroid dehydrogenase:: Potential molecular mechanisms underlying the programming of hypertension in utero [J].
Bertram, C ;
Trowern, AR ;
Copin, N ;
Jackson, AA ;
Whorwood, CB .
ENDOCRINOLOGY, 2001, 142 (07) :2841-2853
[3]   A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [J].
Clément, K ;
Vaisse, C ;
Lahlou, N ;
Cabrol, S ;
Pelloux, V ;
Cassuto, D ;
Gourmelen, M ;
Dina, C ;
Chambaz, J ;
Lacorte, JM ;
Basdevant, A ;
Bougneres, P ;
Lebouc, Y ;
Froguel, P ;
Guy-Grand, B .
NATURE, 1998, 392 (6674) :398-401
[4]   Effect of glucocorticoid excess on the cortisol/cortisone ratio [J].
Dötsch, J ;
Dörr, HG ;
Stalla, GK ;
Sippell, WG .
STEROIDS, 2001, 66 (11) :817-820
[5]   WEIGHT-REDUCING EFFECTS OF THE PLASMA-PROTEIN ENCODED BY THE OBESE GENE [J].
HALAAS, JL ;
GAJIWALA, KS ;
MAFFEI, M ;
COHEN, SL ;
CHAIT, BT ;
RABINOWITZ, D ;
LALLONE, RL ;
BURLEY, SK ;
FRIEDMAN, JM .
SCIENCE, 1995, 269 (5223) :543-546
[6]   FETAL AND INFANT GROWTH AND IMPAIRED GLUCOSE-TOLERANCE AT AGE 64 [J].
HALES, CN ;
BARKER, DJP ;
CLARK, PMS ;
COX, LJ ;
FALL, C ;
OSMOND, C ;
WINTER, PD .
BMJ-BRITISH MEDICAL JOURNAL, 1991, 303 (6809) :1019-1022
[7]   Recombinant leptin for weight loss in obese and lean adults - A randomized, controlled, dose-escalation trial [J].
Heymsfield, SB ;
Greenberg, AS ;
Fujioka, K ;
Dixon, RM ;
Kushner, R ;
Hunt, T ;
Lubina, JA ;
Patane, J ;
Self, B ;
Hunt, P ;
McCamish, M .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1568-1575
[8]   Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans [J].
Krude, H ;
Biebermann, H ;
Luck, W ;
Horn, R ;
Brabant, G ;
Grüters, A .
NATURE GENETICS, 1998, 19 (02) :155-157
[9]   A transgenic model of visceral obesity and the metabolic syndrome [J].
Masuzaki, H ;
Paterson, J ;
Shinyama, H ;
Morton, NM ;
Mullins, JJ ;
Seckl, JR ;
Flier, JS .
SCIENCE, 2001, 294 (5549) :2166-2170
[10]   Congenital leptin deficiency is associated with severe early-onset obesity in humans [J].
Montague, CT ;
Farooqi, IS ;
Whitehead, JP ;
Soos, MA ;
Rau, H ;
Wareham, NJ ;
Sewter, CP ;
Digby, JE ;
Mohammed, SN ;
Hurst, JA ;
Cheetham, CH ;
Earley, AR ;
Barnett, AH ;
Prins, JB ;
ORahilly, S .
NATURE, 1997, 387 (6636) :903-908