Pluripotency and tumorigenicity

被引：32

作者：

Brickman, JM

Burdon, TG

机构：

[1] Univ Edinburgh, Inst Stem Cell Res, Edinburgh EH9 3JQ, Midlothian, Scotland

[2] Roslin Inst, Dept Gene Express & Dev, Roslin EH25 9PS, Midlothian, Scotland

来源：

NATURE GENETICS | 2002年 / 32卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/ng1202-557

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pluripotent stem cells are essential for embryonic development and regeneration of adult tissues. But when the molecular pathways that control stem cells go awry, the result can often be the development of tumors. Wnt signaling mediated by the intracellular transducer β-catenin and the tumor suppressor APC (adenomatosis polyposis coli) is pivotal in embryogenesis and frequently associated with cancer. The investigation of different mutations in Apc that lead to increased levels of β-catenin in pluripotent cells supports the notion that many cancers may result from the dysregulation of stem-cell programs.

引用

页码：557 / 558

页数：2

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