The Case of Oncolytic Viruses Versus the Immune System: Waiting on the Judgment of Solomon

被引：164

作者：

Prestwich, Robin J. ^{[2
]}

Errington, Fiona ^{[2
]}

Diaz, Rosa M. ^{[3
]}

Pandha, Hardev S. ^{[4
]}

Harrington, Kevin J. ^{[5
]}

Melcher, Alan A. ^{[2
]}

Vile, Richard G. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Coll Med, Dept Mol Med, Rochester, MN 55905 USA

[2] Univ Leeds, Leeds Inst Mol Med, Leeds LS9 7TF, W Yorkshire, England

[3] Mayo Clin, Dept Immunol, Rochester, MN 55905 USA

[4] Univ Surrey, Postgrad Med Sch, Guildford GU2 7XX, Surrey, England

[5] Inst Canc Res, Targeted Therapy Lab, Chester Beatty Labs, London SW3 6JB, England

来源：

HUMAN GENE THERAPY | 2009年 / 20卷 / 10期

关键词：

VESICULAR STOMATITIS-VIRUS; HERPES-SIMPLEX-VIRUS; NATURAL-KILLER-CELLS; COLONY-STIMULATING FACTOR; HUMAN DENDRITIC CELLS; CHRONIC LYMPHOCYTIC-LEUKEMIA; POTENT ANTITUMOR IMMUNITY; PHASE-I TRIAL; MEASLES-VIRUS; T-CELLS;

D O I：

10.1089/hum.2009.135

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The three-way interaction between oncolytic viruses, the tumor microenvironment, and the immune system is critical to the outcome of antitumor therapy. Classically, the immune system is thought to limit the efficacy of therapy, leading to viral clearance. However, preclinical and clinical data suggest that in some cases virotherapy may in fact act as cancer immunotherapy. In this review we discuss the ability of oncolytic viruses to alter the immunogenic milieu of the tumor microenvironment, and the role of innate and adaptive immunity in both restricting and augmenting therapy. Strategies to improve virotherapy by immunomodulation, including suppression or enhancement of the innate and adaptive responses, are discussed.

引用

页码：1119 / 1132

页数：14

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