Genes, environment, and time: The Vietnam Era Twin Study of Aging (VETSA)

被引:114
作者
Kremen, William S.
Thompson-Brenner, Heather
Leung, Yat-Ming J.
Grant, Michael D.
Franz, Carol E.
Eisen, Seth A.
Jacobson, Kristen C.
Boake, Corwin
Lyons, Michael J.
机构
[1] Boston Univ, Dept Psychol, Boston, MA 02215 USA
[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[3] Vet Adm Med Ctr, Dept Med, St Louis, MO 63125 USA
[4] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA
[5] Univ Texas, Dept Phys Med & Rehabil, Houston, TX USA
关键词
D O I
10.1375/183242706779462750
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Vietnam Era Twin Study of Aging (VETSA) is a large-scale investigation of cognitive aging from middle to later age. The intended sample of 1440 twin subjects is recruited from the Vietnam Era Twin Registry (VETR), a registry of middle-aged male-male twin pairs who both served in the military during the Vietnam conflict (1965-1975). VETSA employs a multitrait multimethod approach to cognitive assessment to focus on the genetic and environmental contributions to cognitive processes over time, as well as the relative contributions to cognitive aging from health, social, personality, and other contextual factors. The cognitive domains of episodic memory, working memory, abstract reasoning, and inhibitory executive functioning are assessed through neuropsychological testing. In addition, VETSA obtains the participant's score on the Armed Forces Qualification Test, taken at the time of induction into the military around age 20 years, and readministers the test. Two other projects - VETSA Cortisol and VETSA Magnetic Resonance Imaging - are also in progress using subsamples of the VETSA twins. Prior waves of data collection by VETSA investigators using the VETR have provided historical data on physical and mental health, while future waves of VETSA data collection are planned every 5 years. These methods will provide data on multiple phenotypes in the same individuals with regard to genetic and environmental contributions to cognitive functioning over time, personality and interpersonal risk and protective factors, stress and cortisol regulation, and structural brain correlates of aging processes.
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页码:1009 / 1022
页数:14
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