New synthetic vitamin D analogs with antiproliferative activities

被引：9

作者：

Steinmeyer, A ^{[1
]}

Kirsch, G ^{[1
]}

Neef, G ^{[1
]}

Schwarz, K ^{[1
]}

机构：

[1] Schering AG, Inst Med Chem, D-13342 Berlin, Germany

来源：

CURRENT PHARMACEUTICAL DESIGN | 2000年 / 6卷 / 07期

关键词：

D O I：

10.2174/1381612003400470

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The introduction of oxygen atoms into different positions of the vitamin D side chain is described. By combining the arising 23-oxa and 25-oxa elements with other structural modifications (19-nor, iso-19-nor, 20-methyl, 20-ene, 20,21-cyclo) calcitriol analogs with remarkable levels of dissociation between beneficial acitivities on cell growth regulation and undesired hypercalcemia were identified. Structure-activity relations are elaborated in a very systematic outline of the Schering drug finding program in this particular class of vitamin D compounds.

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页码：767 / 789

页数：23

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