Epidermolysis bullosa and cancer

被引：88

作者：

Mallipeddi, R ^{[1
]}

机构：

[1] St Thomas Hosp, Dept Cell & Mol Pathol, St Johns Inst Dermatol, Guys Kings Coll & St Thomas Hosp Med Sch, London SE1 7EH, England

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2002年 / 27卷 / 08期

关键词：

D O I：

10.1046/j.1365-2230.2002.01130.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Epidermolysis bullosa (EB) encompasses a group of inherited blistering skin disorders classified into three main subtypes of simplex, junctional and dystrophic. In recent years there have been substantial advances in our understanding of the molecular basis of these conditions and in the management of such patients. In spite of this progress, squamous cell carcinoma (SCC) is still a major cause of morbidity and mortality, particularly in Hallopeau-Siemens recessive dystrophic EB. The reason why dystrophic EB patients readily develop SCC with such a poor prognosis remains a mystery. This article reviews the epidemiology of cancer in inherited EB and also discusses the clinical features, histological assessment and treatment options of SCC in EB.

引用

页码：616 / 623

页数：8

共 36 条

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