Quorum Sensing in Staphylococci

被引:653
作者
Novick, Richard P. [1 ]
Geisinger, Edward
机构
[1] NYU, Med Ctr, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA
关键词
quorum sensing; autoinduction; staphylococcal pathogenesis; autoinducing peptide; signal receptor;
D O I
10.1146/annurev.genet.42.110807.091640
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The staphylococcal agr locus encodes a quorum sensing (QS) system that controls the expression of virulence and other accessory genes by a classical two-component signaling module. Like QS modalities ill other Gram-positive bacteria, agr encodes all autoactivating peptide (AIP) that is the inducing ligand for AgrC, the agr signal receptor. Unlike other such systems, agr variants have arisen that show strong cross-inhibition in heterologous combinations, with important evolutionary implications. Also unlike other systems, the effector of global gene regulation in the agr-system is a major regulatory RNA, RNAIII. In this review, we describe the functions of the agr system's elements, show how they interact to bring about the regulatory response, and discuss the role of QS in staphylococcal pathobiology. We conclude with the suggestion that agr autoactivation, unlike classical enzyme induction, call occur under suboptimal conditions and call distinguish self from non-self by inducing ail exclusive and coordinated population wide response.
引用
收藏
页码:541 / 564
页数:24
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