COLOR - A randomized clinical trial comparing laparoscopic and open resection for colon cancer

被引:189
作者
Hazebroek, EJ [1 ]
机构
[1] Univ Hosp Dijkzigt, Dept Surg, NL-3015 GD Rotterdam, Netherlands
来源
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2002年 / 16卷 / 06期
关键词
laparoscopy; colorectal cancer; multicenter randomized trial; cancer;
D O I
10.1007/s00464-001-8165-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Laparoscopic surgery has proven to be safe and effective. However, the value of laparoscopic resection for malignancy in terms of cancer outcome can only be assessed by large prospective randomized clinical trials with sufficient follow-up. Methods: COLOR (COlon carcinoma Laparoscopic or Open Resection) is a European multicenter randomized trial that began in 1997. In 27 hospitals in Sweden, The Netherlands, Germany, France, Italy, Spain, and the United Kingdom, 1200 patients will be included. The primary endpoint of the study is cancer-free survival after 3 years. Results: In < 3.5 years, > 850 patients have been randomized for right hemicolectomy (47%). left hemicolectomy (11%), and sigmoidectomy (42%). Fifty seven patients were excluded after randomization. Forty six months after the start of the trial, the overall recurrence rate is 6.8%. The distribution of stage of disease is as follows: stage I, 25%; stage II, 41%; stage III, 32%; stage IV, 2%. Conclusion: Although laparoscopic surgery appears to be of value in the treatment of colorectal cancer, the final, results of randomized trials need to be considered to determine its definitive role. Given the current accrual rate, the COLOR study will be completed in 2002.
引用
收藏
页码:949 / 953
页数:5
相关论文
共 12 条
[1]   SUBCUTANEOUS METASTASES AFTER LAPAROSCOPIC COLECTOMY [J].
BERENDS, FJ ;
KAZEMIER, G ;
BONJER, HJ ;
LANGE, JF .
LANCET, 1994, 344 (8914) :58-58
[2]   Impact of gas(less) laparoscopy and laparotomy on peritoneal tumor growth and abdominal wall metastases [J].
Bouvy, ND ;
Marquet, RL ;
Jeekel, H ;
Bonjer, HJ .
ANNALS OF SURGERY, 1996, 224 (06) :694-701
[3]  
FLESHMAN JW, 1996, DIS COLON RECTUM S, V39, P53
[4]  
FRANKLIN ME, 1996, DIS COLON RECTUM S, V39, P35
[5]  
HEWETT PJ, 1996, DIS COLON RECTUM S, V39, P62
[6]   Laparoscopic resection does not adversely affect early survival curves in patients undergoing surgery for colorectal adenocarcinoma [J].
Poulin, EC ;
Mamazza, J ;
Schlachta, CM ;
Grégoire, R ;
Roy, N .
ANNALS OF SURGERY, 1999, 229 (04) :487-492
[7]  
Santoro E, 1999, HEPATO-GASTROENTEROL, V46, P900
[8]  
Tominaga T, 1996, CANCER, V78, P403
[9]   Port-site metastases - Impact of local tissue trauma and gas leakage [J].
Tseng, LNL ;
Berends, FJ ;
Wittich, P ;
Bouvy, ND ;
Marquet, RL ;
Kazemier, G ;
Bonjer, HJ .
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES, 1998, 12 (12) :1377-1380
[10]  
VUKASIN P, 1996, DIS COLON RECTUM, V39, P20