Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia

被引:24
作者
Griesshammer, M [1 ]
Heinze, B [1 ]
Bangerter, M [1 ]
Heimpel, H [1 ]
Fliedner, TM [1 ]
机构
[1] UNIV ULM, DEPT CLIN PHYSIOL, D-89081 ULM, GERMANY
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 1997年 / 75卷 / 11-12期
关键词
karyotype abnormalities; chronic myeloid leukemia blast crisis;
D O I
10.1007/s001090050173
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We examined karyotypes and their prognostic significance in a series of 122 patients with chronic myeloid leukemia in blast crisis, Of 73 patients cytogenetically examined at the onset of blast crisis 63% had developed secondary cytogenetic abnormalities in addition to the Philadelphia chromosome. These newly emerging abnormalities included a double Philadelphia chromosome in 20 patients, a trisomy 8 in 17, ansi an isochromosome 17q in 11 patients. Development of such additional karyotypic abnormalities was significantly associated with a shorter median survival and less response to cytoreductive treatment and was significantly more common in nonlymphoid blast crisis than in the lymphoid-type blast crisis, Thus, assessment of karyotypes at the onset of chronic myeloid leukemia blast crisis appears to be of prognostic significance for both remission duration and survival.
引用
收藏
页码:836 / 838
页数:3
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