Familial, medical and developmental patterns of children with autism and a history of language regression

Autism is a developmental disorder characterized by impairments in social and communication skills, as well as repetitive and stereotypical patterns of behavior. A common feature of children with autism is regression or loss of spoken words. The aim of this study was to systematically review medical and familial conditions in children with autism with regression and those without regression in order to determine relevant factors, in regard to regression, that might lead to identifying factors in etiology. Eighty-two children with autism were evaluated by a multidisciplinary team. In addition, medical and familial information was collected on each child in order to determine any differences between the children with regression and those without. Results confirmed previous findings of minimal differences in child characteristics, family history, prenatal and perinatal factors, developmental concerns, behavioral concerns, and medical findings in children who regress.