Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea

被引：83

作者：

Morita, H ^{[1
]}

Shimbo, K ^{[1
]}

Shigemori, H ^{[1
]}

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)00029-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A unique bicyclic peptide, moroidin (1), from the seeds of Celosia argentea (Amaranthaceae) strongly inhibited the polymerization of tubulin. The stereostructure of moroidin (1) was reinvestigated by spectroscopic data, chemical degradation, and molecular dynamics simulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：469 / 471

页数：3

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