Carotenoids and transcription

被引：78

作者：

Sharoni, Y ^{[1
]}

Danilenko, M

Dubi, N

Ben-Dor, A

Levy, J

机构：

[1] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, Beer Sheva, Israel

[2] Soroka Med Ctr, IL-84101 Beer Sheva, Israel

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 430卷 / 01期

关键词：

cancer prevention; phase II enzymes; antioxidant response element; retinoid receptors; xenobiotic receptor; peroxisome proliferator-activated receptor;

D O I：

10.1016/j.abb.2004.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible involvement of several transcription systems in the anticancer activity of carotenoids is the focus of this review. Carotenoids modulate the basic mechanisms of cell proliferation, growth factor signaling, gap junctional intercellular communication, and produce changes in the expression of many proteins participating in these processes. The changes in the expression of multiple proteins suggest that the initial effect of carotenoids involves modulation of transcription. We and others have found evidence for the role of several transcription systems, such as the retinoid receptors, activator protein-1 (AP-1), peroxisome proliferator-activated receptors (PPAR), xenobiotic receptors and the antioxidant response element (ARE), in the anticancer activity of carotenoids. The observed modulation of a network of transcription systems may provide the molecular basis for the synergistic anticancer effects of the combinations of various carotenoids together with other dietary and pharmacologic compounds. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：89 / 96

页数：8

共 79 条

[1] Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells [J].