Pathogenesis of age-related macular degeneration

被引：47

作者：

Tezel, TH ^{[1
]}

Bora, NS ^{[1
]}

Kaplan, HJ ^{[1
]}

机构：

[1] Univ Louisville, Kentucky Lions Eye Ctr, Dept Ophthalmol & Visual Sci, Louisville, KY 40202 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1016/j.molmed.2004.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world. The inability to prevent the development of AMD and its complications stems from our lack of knowledge of the underlying pathological mechanisms. A recent report described a rodent with chemokine deficiencies that developed retinal changes similar to those frequently observed in AMD and suggested an important role for macrophages and complement in the pathogenesis of this disease. Such novel insights into the possible causes of AMD might give rise to preventative and/or reconstructive treatments in the future.

引用

页码：417 / 420

页数：4

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